Cell Signaling and Cancer

In this course the major cell signaling pathways involved in cancer cell development will be examined. An initial overview of signaling (cytosolic, nuclear, dual-address), receptors and basic second messenger pathways (PKA/PKC) will be followed by an in-depth study of pathways of particular relevance to cancer such as receptor tyrosine kinases, RAS, PI3 kinase/ PTEN, growth factors (e.g. EGF, TGF-#), integrins, Wnt/#-catenin and JAK/STAT pathways.